|
|
conductive bio-copolymers based on pectin-polycaprolactone/polyaniline and tissue engineering application thereof
|
|
|
|
|
نویسنده
|
sarvari raana ,nouri mohammad ,roshangar leila ,gholami farashah mohammad sadegh ,sadrhaghighi amirhouman ,agbolaghi samira ,keyhanvar peyman
|
منبع
|
journal of ultrafine grained and nanostructured materials - 2021 - دوره : 54 - شماره : 1 - صفحه:64 -72
|
چکیده
|
Development of biopolymers possessing both biodegradable and electrically conducting properties has attracted a huge interest in the biomedical field. these systems have some benefitials in wound healing and reducing the long-term health risks. in this study, the pectin-polycaprolactone (pec-pcl) copolymers were synthesized by ring-opening polymerization. subsequently, the solutions of the synthesized pec-pcl and homopolyaniline (h-pani) were blended in various ratios and their conductivity properties were measured by cyclic voltammetry and the composition of 80:20 was selected for electrospinning process because of the suitable electroactive behavior and biodegradability. the morphology, biocompatibility, hydrophilicity, and mechanical properties of the nanofibers were thoroughly investigated. resulted scaffolds represented a porous structure with large surface area (110–130 nm) and young’s modulus of 1615 ± 32 mpa, which imitated the natural microenvironment of extra cellular matrix (ecm) to regulate the cell attachment, proliferation and differentiation. the results demonstrated that these electrospun nanofibers could be potentially applied in biomedical such as tissue engineering.
|
کلیدواژه
|
conductive polymer; pectin; pcl; polyaniline; biodegradability
|
آدرس
|
tabriz university of medical sciences, infectious and tropical diseases research center, iran, tabriz university of medical sciences, faculty of advanced medical sciences, department of reproductive biology, iran, tabriz university of medical sciences, stem cell research center, iran, tabriz university of medical sciences, stem cell research center, iran, tabriz university of medical sciences, faculty of dentistry, department of orthodontics, iran, azarbaijan shahid madani university, faculty of engineering, chemical engineering department, iran, tabriz university of medical sciences, tabriz university of medical, stem cell research center, stem cells and regenerative medicine institute, school of advanced medical sciences, department of medical nanotechnology, iran. universal scientific education and research network (usern), convergence of knowledge, technology and society network (cktsn), iran. artan1100 startup accelerator, iran
|
پست الکترونیکی
|
regenerative.md@gmail.com;keyhanvarp@tbzmed.ac.ir
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|