An assessment effect of low tidal volume ventilation in on-pump Coronary artery bypass graft surgery on postoperative pulmonary complications: A double-blind, randomized clinical trial

Introduction: this double blind randomized clinical trial aimed to assess effect of low tidal volume ventilation in on-pump coronary artery bypass graft (cabg) surgery on postoperative pulmonary complications. methods: this study was conducted in baqiyatallah hospital from june 2021 to june 2022. 60 patients asa class 1 and 2 cabg candidates were randomly divided into two intervention and control groups. patients in the intervention group receive ventilation with a tidal volume (3-4 ml/kg) and several 6-8 breaths/minute. the control group doesn't receive any ventilation per the hospital routine after undergoing cardiopulmonary bypass (cpb). renal and hepatic parameters are recorded before and on the first, second, and third days after surgery. vital signs, duration of mechanical ventilation in icu-oh, and duration of hospitalization in intensive care unit (icu) were recorded. results: the average age of the patients was 57.43 ± 9.82 years. thirty-nine patients (65.0%) were male. the average hb, two days after the operation in the first group was lower than the second group (p=0.019) .the average cr, three days after the operation in the first group, was higher than the second group (p=0.037) .the average sgpt, three days after the operation in the first group was higher than the second group (p=0.031) .the average sgot after surgery in the first group was higher than in the second group. the average alk, two days and three days after surgery in the first group was higher than in the second group. the average crp, three days after the operation in the first group was lower than the second group (p=0.001).conclusion: this research showed no significant difference in the two groups’ average operation duration, ultrafiltration volume, x clamp duration, icu hospitalization duration, mechanical ventilation duration, and cpb duration. management of ventilation during cardiovascular surgery is challenging.