Prognostic factors for in-hospital mortality in neonates with Covid-19: a cross-sectional study in south of Iran

Introduction: due to high neonatal, maternal mortality and adverse pregnancy outcome, covid-19 in neonates is concerned. this study aimed to determine the prognostic factors for in-hospital mortality in neonates with covid-19.methods: this retrospective cross-sectional study (february-november 2020) was performed on infected neonates (<60 days) who were clinically diagnosed as covid-19 and were hospitalized in covid-19 wards in shiraz university of medical sciences affiliated hospitals, southern iran. data were extracted from the patients' medical files, and were gathered in a data collecting form; including demographic characteristics, laboratory and clinical outcome. the patients were categorized as survivor and non-survivors groups, and then were compared.results: totally, 96 neonates were enrolled. the mean±sd of age was 13.01±10.88 days, and most of them were in the age group of 6-15 days (33.3%). fifty-nine (61.5%) was male. the mortality rate was 12.5%. lower gestational age (p=0.031), and the more frequency of having underlying diseases (p=0.010) was observed in non-survivors. the most signs and symptoms were respiratory distress (58.3%), lethargy (46.9%), and poor feeding (37.5%). pulmonary radiological involvement was more in non-survivors (p<0.001), and it was more severe in these patients (p<0.001). the results of multivariate logistic regression model showed that only receiving ivig (or=20.2, p<0.001) was the independent predictor factor for in-hospital mortality in these patients. conclusions: the in-hospital mortality was obtained as 12.5% in the current study, and only receiving ivig was the independent predictor factor for in-hospital mortality in neonates with covid-19.