Comparison the efficacy of Hypericum perforatum and vitex agnus-castus in hot flushes: A double-blinded randomized controlled trial

Background: treating hot flushes in middle-aged women is an important health issue. recently, hypericum perforatum and vitex agnus-castus were investigated to decrease hot flushes. this study was conducted to compare the efficacy of hypericum perforatum and vitex agnus-castus in hot flushes among menopausal women. methods: this was a randomized, double-blinded, controlled trial. the hypericum perforatum group received 330 µg hypericum perforatum and second group received vitex agnus-castus in the same tablet forms. data were analyzed using repeated measurement for comparing greene climacteric scale.results: trend of greene climacteric scale and hot flushness attack were decreased in both groups and it presented a decreasing trend within two months; however, no statistically significant difference was observed between the two groups.conclusion: it seems that hypericum perforatum and vitex agnus-castus could be similarly effective in decreasing hot flushes. these two medicines did not have any special severe side effects.