the systemic inflammatory response index as a novel diagnostic tool for acute appendicitis

Objective: this study aimed to assess the potential of the systemic inflammatory response index (siri) fordiagnosing aa, its possible advantages over current methods, and its utility in distinguishing uncomplicatedfrom complicated appendicitis.methods: in this cross-sectional study, 240 patients scheduled for appendectomy with a diagnosis of aa wereenrolled. demographic information, clinical and paraclinical findings, including complete blood count (cbc),alvarado score, siri, sonography findings, and pathology results, were documented. data were analyzed usingspss software version 26.results: of the 240 patients, 106 (44.2%) were men, and 134 (55.8%) were women, with a mean age of 37.49±15.55years. final pathology reports identified 26 (10.8%) cases of a normal appendix, 176 (73.3%) with uncomplicatedappendicitis, 23 (9.6%) with complicated appendicitis, and 15 (6.3%) with reactive lymphoid hyperplasia. siridemonstrated significant differences across the pathology groups (p<0.0001). it showed notable discriminationbetween normal and complicated appendicitis (p=0.005), normal and combined appendicitis (p=0.008), andsuggestive differences for normal versus uncomplicated (p=0.021) and uncomplicated versus complicatedcases (p=0.044). similarly, alvarado scores showed significant differences, particularly between the normaland complicated appendicitis groups.conclusion: the siri and alvarado scoring systems showed significant potential for diagnosing appendicitiswith acceptable sensitivity and specificity. they might also assist in differentiating between uncomplicated andcomplicated appendicitis.