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   Effects of Flaxseed Oil and Olive Oil on Markers of Inflammation and Wound Healing in Burn Patients: A Randomized Clinical Trial  
   
نویسنده ghanbari atefeh ,masoumi sanaz ,kazemnezhad leyli ehsan ,mahdavi-roshan marjan ,mobayen mohammadreza
منبع bulletin of emergency and trauma - 2023 - دوره : 11 - شماره : 1 - صفحه:32 -40
چکیده    Objectives: to study the anti-inflammatory and antioxidant effects of flaxseed oil and olive oil on inflammatory markers for facilitating wound healing. methods: one hundred and twelve patients were randomly selected to four groups with a total burn surface area (tbsa) of 20-50%. the four groups includes olive oil (oo), flaxseed oil (fo), mixture of olive oil andflaxseed oil (of), and control group and received 30g of oils for three weeks. serum high-sensitivity c-reactive protein (hs-crp), ferritin and albumin level as inflammatory markers, as well as cholesterol, triglyceride, high-density lipoprotein (hdl) and low-density lipoprotein (ldl) as the lipid profile were explored. wound healing was assessed by photographing on days 2, 8, 15, and 22 (during three weeks of intervention) and were analyzed in imagej software. results: the greatest reduction in the level of hs-crp and ferritin was observed in the of (-21.38±44.41) (-132.79±165.36), while the lowest reduction was reported in the control group (-36.36±79.03) (141.08±262.36). compared to control group, oo significantly increased albumin (0.88±0.65). reduction of wound healing at the end of the first week of intervention was not significant in the study groups. however, the stereology examination showed significant improvement in wound healing at the end of the second and third weeks in the of.conclusion: based on the findings, combination of herbal oils reduce inflammation and improve wound healing and showed positive effects on the size of wounds in burn patients.
کلیدواژه Flaxseed oil; Olive oil; Burn; Wound; Inflammation indices
آدرس guilan university of medical sciences, social determinants of health research center (sdhrc), school of nursing and midwifery, department of nursing (medical.surgical), Iran, guilan university of medical sciences, burn and regenerative medicine research center, velayat burn university hospital, Iran, guilan university of medical sciences, social determinants of health research center (sdhrc), school of nursing and midwifery, department of bio.statistics, Iran, guilan university of medical sciences, cardiovascular diseased research center, heshmat hospital, school of medicine, department of cardiology, Iran, guilan university of medical sciences, burn and regenerative medicine research center, Iran
 
     
   
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