Procalcitonin and D-dimer for Predicting 28-Day-Mortality Rate and Sepsis Severity based on SOFA Score; A Cross-sectional Study

Objective: to determine the possible relationship of procalcitonin (pct) and d-dimer with the 28-daymortality rate and severity of sepsis based on sequential organ failure assessment (sofa) score. methods: in this cross-sectional study, patients were enrolled based on their signs and symptoms of sepsis confirmed by essential laboratory studies. demographic data, glasgow coma scale and vital signs, serum pct and d-dimer levels, creatinine, bilirubin level, arterial blood gas analysis and platelet count were recorded. disease severity index was assessed based on sofa score. patients’ 28-day-mortality rate and hospital length of stay were compared with the study variables. results: sixty-four patients with the mean age of 78.3±11.6 were included of whom 34 cases (53.1%) were male. the 28-day-mortality rate was 17%. the analysis showed that only patients’ age (p=0.01) and platelet count (p=0.02) had a statistically significant association with the mortality rate. sofa score had no statistically significant correlation with pct or d-dimer; and these two markers didn’t have any significant correlation in terms of predicting mortality due to the sepsis. conclusion: in our study, pct and d-dimer failed to show any significant correlation with 28-day-mortality rate of sepsis.