Healing Effects of Dried and Acellular Human Amniotic Membrane and Mepitelas for Coverage of Skin Graft Donor Areas; A Randomized Clinical Trial

Objective: to compare the healing effects of dried and acellular human amniotic membrane and mepitel for coverage of split-thickness graft donor site (stgds). methods: twenty patients who underwent stgds regeneration surgery in identical anatomic regions were enrolled in this randomized controlled clinical trial conducted in hazrate fatemeh hospital (iran). patients were randomly assigned in 3 groups of wound dressing; group a by mepitel, group b amicare (dried amniotic membrane) and group c ocureg-a (acellular amniotic membrane). re-epithelization rate (healing time), pain sensation, scar formation and infection rate were assessed till complete healing was achieved. results: our results showed no significant difference between amicare, ocureg-a and mepitel in the features analyzed by us including: re-epithelization rate (healing time) p=0.573, pain sensation p=day 4^ th: 0.131, day 8^ th: 0.93 and day 12^ th: 0.365, scar formation p>0.05 and infection rate. conclusion: our findings confirmed the safety and efficacy of amicare (dried amniotic membrane) and ocureg-a (acellular amniotic membrane) in treatment of split-thickness donor site in comparison with mepitel as a standard wound dressing.