Effects of Aloe Vera and Chitosan Nanoparticle Thin-Film Membranes on Wound Healing in Full Thickness Infected Wounds with Methicillin Resistant Staphylococcus Aureus

Objective: to assess effect of aleo vera with chitosan nanoparticle biofilm on wound healing in full thickness infected wounds with antibiotic resistant gram positive bacteria. method: thirty rats were randomized into five groups of six rats each. group i: animals with uninfected wounds treated with 0.9% saline solution. group ii: animals with infected wounds treated with saline. group iii: animals with infected wounds were dressed with chitosan nanoparticle thin-film membranes. group iv: animals with infected wounds were treated topically with aloe vera and group v: animals with infected wounds were treated topically with aloe vera and dressed with chitosan nanoparticle thin-film membranes. wound size was measured on 6, 9, 12, 15, 18 and 21days after surgery. results: microbiology, reduction in wound area and hydroxyproline contents indicated that there was significant difference (p<0.05) between group v and other groups. quantitative histological studies and mean rank of the qualitative studies demonstrated that there was significant difference (p<0.05) between group v and other groups. conclusion: the aloe vera with chitosan nanoparticle thin-film membranes had a reproducible wound healing potential and hereby justified its use in practice.