Toxicological evaluation of methanol extract of Khaya senegalensis leaves in African catfish Clarias gariepinus

The toxicity of methanol extract of khaya senegalensis leaves was evaluated in clarias gariepinus over 96 h exposure. the fish were exposed to 150 mg/l. 170 mg/l. 190mg/l, 210 mg/l and 230 mg/l of the extract and a control in acute static bioassay after a trial finding to determine the median lethal concentration (lc50) of the extract. exposed fish showed clinical signs, such a distress opercula ventilation, tail fin beats and respiratory alteration. the frequency of opercula ventilation and tail fin beats were concentration dependent and showed significant association (p<0.05). the lc50 value of 199,69mg/l was established for the extract in the exposed fish where mean mortally was significantly (p<0.05) concentration and exposure dependent. this plant is to be regarded as a piscine toxicant and should be discarded from the bank of rivers and dams