Ethanolic Extract of Ground Vernonia Amygdalina Stem Exhibited Potent Antibacterial Activity and Improved Hematological Bio-Functional Parameters in Normal and Monosodium Glutamate-Intoxicated Rats

Herein, vernonia amygdalina stem ethanolic extract, vasee, was elucidated for its antibacterial activity in vitro by disk-diffusion technique and, in vivo effect on some hematological parameters of normal and monosodium glutamate, msg-intoxicated rats. for in vivo study, 20 male albino rats assigned into five groups (a, b, c, d, and e) were, for 14 days, respectively administered msg (8000 mg/kg body weight, bw), vasee (200 mg/kg bw), control (vital feed and tap water), msg (8000 mg/kg bw + vasee, 200 mg/kg bw), and msg (8000 mg/kg bw + vasee, 400 mg/kg bw). in vitro, the vasee-related activity against the tested bacterial pathogens was significant (p < 0.05), dose dependent and comparable to that by the standard antibacterial drug, ciprofloxacin. in vivo, vasee compared to control and msg groups improved (p < 0.05) and, notably at the highest tested dose modulated the monosodium glutamate intoxication-related effect on, the studied hematology of rats. thus, vasee exhibited potent activity against the tested bacterial pathogens, improved, and potentially modulated msg-intoxication-related effect on, the rats’ hematological functions. the study underscored a promising antibacterial application of the extract of hitherto wasted bitter leaf stem that could offer novel therapeutic benefits on the hematology of especially msg- intoxicated rats, warranting further studies.