Analgesic and Anti-inflammatory Activities of the Stem

Peltophorum pterocarpum (family; fabaceae) is an evergreen perennial crop grown in tropical gardens. different parts of this tree are being used for the management of many diseases. this study investigated the acute toxicity, analgesic and anti-inflammatory potentials of n-hexane extract of p. pterocarpum stem bark. acute oral toxicity of n-hexane extract of p. pterocarpum stem bark was investigated using standard method. analgesic activity was investigated by using acetic acid-induced writhing model, using indomethacin as a reference drug. antiinflammatory activity of n-hexane extract of p. pterocarpum stem bark was investigated by using formalin- induced paw licking model, using aspirin as standard drug. in the acute toxicity study, mortality was observed at 500 and 2500 mg/kg body weight. in the acetic acid induced writhing test, the n-hexane extract of p. pterocarpum (100 and 200 mg/kg body weight) showed a significant reduction in the number of writhing with 55.5 % and 60 % of inhibition respectively. in formalin-induced rat paw oedema test for acute inflammation, the n-hexane extract of p. pterocarpum in 50, 100 and 200 mg/kg body weight showed 26.00 %, 27.89 % and 32.27 % inhibition of oedema respectively after 4hours, which is comparable to that of standard drug-aspirin (33.59 %). these results validated that the extract of p. pterocarpum possesses significant analgesic and anti-inflammatory properties.