Synthesis, Characterization and Antimicrobial of Schfiff Base from 5-Bromo – Salicylaldehyde and P-Toluidine

As pathogens in recent times have developed resistance to the existing antibiotics, the demand for new and more effective antimicrobial agents is a continuous phenomenon. the study involves the synthesis of schiff base from 5-bromo- salicylaldehyde and para-toluidine.the synthesized compounds (5-bromo – salicylaldehyde and the schiff base-n-(5-bromo-2-hydroxybenzylidene) para-toluidine) were evaluated for antimicrobial activities against different bacteria strains using the agar well diffusion method. the 5-bromosalicylaldehyde and its schiff base indicated dose dependent activity as concentration increases from 125mg/ml to 1000mg/ml and inhibitory zones were found to increase mostly for escherichia coli. the two compounds synthesized have indicated high antimicrobial activities on the selected germs and as such can be a drug precursor to microbial infections with further research.