Comparing the Effects of Tranexamic Acid and Mefenamic Acid in IUD-induced Menorrhagia: Randomized Controlled Trial

Backgroundintrauterine device (iud) is a safe and efficient method for preventing pregnancy favored by manywomen. menorrhagia is the most common complication of using copper iud. we aimed to compare theeffect of tranexamic acid and mefenamic acid on the reduction of copper iud-induced menorrhagia.methodsin this randomized controlled trial, 84 women who were using iud (tcu-380) with complaints ofmenorrhagia were randomly divided into two equal groups (mefenamic acid and tranexamic acid).the pictorial blood assessment chart (pbac) was used to measure their bleeding rate. these groupsused the capsules in two consecutive cycles and pbac chart was completed for the samples in threeconsecutive cycles. the results were analyzed using statistical tests and spss software.resultstranexamic acid significantly reduced the amount of bleeding compared with mefenamic acid in thefirst cycle (p < 0.05). a significant difference was seen in mean bleeding days in the two groups beforeand after treatment during the first month (p < 0.05). in the second cycle, both drug treatments wereequally influential on the reduction of bleeding days and decreased the bleeding period. in both groups,a significant difference was observed between the first and second cycles of treatment (p < 0.05).conclusiontreating iud-induced menorrhagia (tcu380) using tranexamic acid was more effective thanmefenamic acid in emergency setting for reducing bleeding days and amount of bleeding. also, it hadfaster treatment effects in decreasing the amount and number of bleeding days.