Research and Application of Razi Theory With Conventional Medicine in Natural Childbirth

Objective: Aging is associated with some changes in the liver function including increased collagen deposition and decreased mitochondrial function. This study aims to evaluate the effect of resistance exercise and vitamin C intake on the expression of Peroxisome ProliferatorActivated Receptor Gamma; Coactivator1 alpha; (PGC1 alpha;) and Mitofusin 1 (MFn1) genes and collagen deposition in older rats.Methods: This is an experimental study conducted on 25 male Wistar rats aged 24 weeks and weighted 280320 g. They were randomly divided into five groups of young control, older exercise, older vitamin C, older exercise + vitamin C, and older control. In the supplementation groups, rats were given liposomal vitamin C (100 mg/kg per body weight) by gavage daily. Oneway ANOVA was used to examine the difference between the groups and Tukey rsquo;s post hoc test was used to determine the location of group differences. For all analyses, the significance level was set at 0.05.Results: Aging significantly reduced the expression of PGC1 alpha; and MFn1 and increased collagen deposition in the liver tissue of rats (P=0.001). In the older exercise + vitamin C group, a significant increase in PGC1 alpha; expression was observed compared to the older control group (P=0.001), but there was no significant changes in MFn1 expression. A significant decrease in collagen deposition was reported in the older exercise, older vitamin C, and older exercise + vitamin C groups compared to the older control group (P=0.001).Conclusion: Resistance exercise combined with vitamin C intake reduces collagen deposition in liver tissue and increases PGC1 alpha; expression in older rats.