Electrocardiography Adverse Effects Systemic Glucantime in a Child With Cutaneous Leishmaniosis: A Case Report and Brief Review

Background: antimonial compounds are the most common choice for the treatmentof cutaneous leishmaniosis (cl). antimonial toxicities are common and cardiac toxicityis one of them, which leads to the electrocardiogram (ecg) changes. in this study, ecgchanges in a patient with cl, who received systemic glucantime, were evaluated.objectives: a 7-year-old girl was admitted to amir-kabir hospital with the complaint ofskin lesions (cl) on her left leg from ten months ago. the patient had received glucantime(10-20mg/kg/day) as a treatment for two 15-day periods and unfortunately, she had notresponded to the treatment. due to the cardiac side effects of glucantime, cardiologyconsultation was requested and an ecg was performed for the patients during theadministration of treatment for the third time. several ecg changes were detected,including first-degree block, right bundle branch block (rbbb), and qtc prolongation. thecardiologist stopped the treatment with glucantime to improve the ecg changes, and anecg was taken every week. even though prolonged qt interval and rbbb improved aftera month, the first-degree block was present for ten months.conclusions: ecg monitoring is necessary prior to and during the treatment with thisdrug. moreover, rbbb has not been commonly reported in other studies. thus, it shouldbe considered as one of the cardiac side effects of glucantime and needs more attention.