The Mechanism of Action and Potential Impact of Flaxseed on Gastrointestinal Manifestations in Cystic Fibrosis: A Narrative Review

Background: cystic fibrosis (cf) is an inherited disease, which leads to death at a young age. nodefinite treatment has yet been found for cf. therefore, it is important to find new therapeuticand medicinal approaches for cf. flaxseed is an antioxidant dietary and anti-inflammatorysupplement with a high omega-3 fatty acid content.objectives: in this article, the mechanism of action of flaxseed as a novel supplementaltreatment for cf is discussed.methods: in this review, we searched iranian traditional medicine (itm) sources, such as zakhirekharazmshahi and canon of medicine. then, from inception to october 2020, data sources,including google scholar and pubmed in the english language were comprehensively exploredfor the mechanism of action of this herbal remedy on cf.results: flaxseed may possess effects on cf gastrointestinal disorders due to its properties,including consumer acceptance as a functional food, being the best non-animal reservoir ofomega 3 fatty acid, alpha-linolenic acid (ala), and soluble fiber, as well as its anti-inflammatoryand antibacterial effects with modulating intestinal microbiota.conclusions: regarding the mentioned potential mechanisms of action, it could be hypothesizedthat flaxseed can be served as a novel medicine for cf.