Predisposing Factors of Cerebral Edema in Pediatric Diabetic Ketoacidosis: A Systematic Review

Background: diabetic ketoacidosis (dka) is not the most common acute complication of type 1diabetes in children and adolescents, but the cerebral edema caused by it is the most commoncause of death in children with dka.objectives: the purpose of this study was to systematically review the literature to describe thepredisposing factors of cerebral edema in pediatric dka.methods: six international databases of wiley, medline, scopus, web of science, proquest, andcochrane library, and three domestic databases, including sid, magiran, and iranmedex weresearched for relevant studies. then, articles with inclusion criteria and related to the objectives ofthis study were reviewed.results: these studies have identified several risk factors for cerebral edema, some of which arerelated to the severity of the disease on admission and some are related to treatment.conclusions: preventing dka is the only reliable way to prevent cerebral edema until the causesof this life-threatening complication are fully understood.