Effect of Vitamin D Supplementation on Serum Lipid Profiles in Children and Adolescence: A Meta-analysis

Background: vitamin d deficiency is an important risk factor for some chronic diseases.some reports suggested that there is an interrelationship between lipids and cholecalciferol.objectives: this meta-analysis was conducted to summarize the existing evidence ofrandomized controlled trials (rcts) to evaluate the effect of vitamin d supplementation onlipid profiles in children and adolescents.methods: in this systematic review and meta-analysis, databases, such as web of science,pubmed, scopus, google scholar, embase, sciencedirect, magiran, and sid were searchedfor studies up to december 21, 2019. this study was conducted according to prismaguidelines. i-square was used to measure the existing heterogeneity through includedarticles. considering heterogeneity among articles, random-effect models were applied topool standardized mean differences (smd) as overall effect size. study eligibility criteriaincluded children and adolescents (<18 years) and evaluation of the association betweenvitamin d and lipid profile. a p<0.05 was considered statistically significant and the analyseswere conducted by stata 14.0.results: a total of 13 trials (number of participant=173) were included in the current metaanalysis.the smd was 0.23, the vitamin d supplementation was associated with a significantslight increase in high-density lipoproteins (hdl) levels in children and adolescents (smd0.23; 95% ci, 0.02, 0.45, p=0.036; i2=57.7%, egger’s p=0.554). we found no significantassociation between vitamin d supplementation and ldl-cholesterol (smd -0.10; 95%ci, −0.29, 0.09, p=0.310; i2=0.0%, egger’s p=0.689), total cholesterol (smd –0.01; 95% ci,−0.20, 0.18, p=0.926; i2=0.0%, egger’s p=0.005), and triglycerides (smd -0.10; 95% ci, −0.22, 0.02, p=0.093; i2=0.0%, egger’s p=0.160) levels.conclusions: vitamin d can marginally increase hdl levels, without any significant effecton ldl-c, tg, and tc levels.