Vitamin D Intoxication in Three Children With Varied Manifestations:A Case Series and Review

Background: inadvertent and erroneous prescription of vitamin d beyond the recommendeddosage and route of administration can cause vitamin d intoxication in children. infants areparticularly vulnerable to such toxicity. clinical features are due to hypercalcemia, ranging from mildto life-threatening symptoms. we report two infants and one child who had varied manifestationsdue to hypercalcemia resulting from empirical treatment with high doses of vitamin d. we discussthe management strategies in these cases along with a brief review of the literature.case presentation: our first case was a 10-month-old infant who presented with fever, vomiting,and failure to thrive. our detailed clinical examination and investigation revealed hypertensionand bilateral nephrocalcinosis along with urinary tract infection. the second child was a 2-yearoldgirl with severe hypercalcemia with clinical features mimicking acute bacterial meningitis.the third infant had mild symptoms like constipation and irritability, and investigations showedmoderate hypercalcemia. all had a history of inappropriate vitamin d administration, either inoral or parenteral form, and they were all successfully treated.conclusions: these case series highlight the importance of proper dosage, avoidance ofparenteral route, along with appropriate clinical and biochemical monitoring during the course,whenever a dose of vitamin d is advised.