hepatobiliary involvement in neonates with covid-19 infection: a narrative review

Background: the most common symptoms in neonates with severe covid-19 infection have been respiratory problems. the virus may adversely affect organs such as the liver. methods: studies focusing solely on liver involvement in newborns with covid-19 infection were searched in pubmed, scopus, and google scholar databases. eight studies were finally reviewed.results: direct viral invasion (covid-19-induced hepatitis or systemic inflammatory response) and drug-induced may contribute to liver damage in neonates. sars-cov-2 may be the latest spark in toxoplasmosis, other agents, rubella, cytomegalovirus, herpes infections, and fetal liver involvement may be induced by transplacental transmission. conclusions: hepatic dysfunction is infrequent but important in neonates with covid-19 infection and the mechanism of liver damage associated with covid-19 may differ from that in adults.