humoral and complement systems in children with acute immune thrombocytopenic purpura

Background: immune thrombocytopenia (itp) is an autoimmune disorder associated with decreased platelet production and accelerated platelet destruction. an impaired immune system may induce by or be associated with itp. objectives: this study aimed to evaluate complement and humoral immune systems in itp. methods: we evaluated 30 children (under 19 years old) with acute and chronic itp referred to a tertiary hospital and compared them with 30 healthy volunteers. we assessed the samples’ cbc with differentiation, serum immunoglobulins (igg, ige, igm, iga, igg1, igg2, igg3, igg4) by nephelometry, antistreptolysin o titer by agglutination, ch50, c3, c4 by nephelometry, cd19 by flow cytometry, and anti-tetanus antibody titer by elisa. their demographic data were obtained with a questionnaire. results: our findings showed that humoral and complement components were normal in both patients and healthy groups. however, based on independent t test results, the mean serum levels of igm, ige, igg1, c3, and tetanus antibody levels were significantly higher in the patient group. conclusions: humoral and complementary immunodeficiency in these patients is unlikely. however, more studies with larger sample sizes are needed.