the relationship between serum and cerebrospinal fluid concentrations of zinc in febrile seizure

Background: febrile seizure (fs) which has different causes, is the most prevalent seizure type in children. studies supported the role of zinc (zn) in fs. objectives: the present study aimed to evaluate the serum and cerebrospinal fluid (csf) zn level in children with fs. methods: this cross-sectional study was performed on 50 patients with fs aged 6 months-6 years in amirkola children’s hospital in 2013-2014. the required demographic and clinical data were recorded employing a checklist. the serum and csf zn levels were determined using atomic absorption spectrophotometry (aas) method. the collected data were analyzed in spss using the chi-squared teste, independent samples t-test, and pearson correlation coefficient. results: the mean±sd age of the explored patients was 12.78±8.38 months and their mean±sd serum zn level was equal to 0.68±0.62 μg/l. in total, 34(68%) of these 50 children presented zn deficiency. the mean±sd csf zn level was measured as 33.29±11.84 μg/l. moreover, the mean±sd csf zn level was equal to 37.71±10.82 and 31.21±11.87 in normal and abnormal serum zn groups, respectively. in terms of mean csf zn level, there was no significant difference between the studied patients with healthy and decreased serum zn level; (p=0.07). no significant difference was found between the demographic/clinical characteristics of the investigated patients with fs and normal/abnormal serum levels of zn (p>0.05). conclusions: the obtained data revealed that a significant number of patients with fs had decreased serum zn level; however, no association was detected between serum and csf zn concentration levels.