investigation of the chronic effects of winstrol and oxandrolone anabolic steroids on liver enzymes in male bodybuilding athletes

Background: chronic use of anabolic-androgenic steroids (aas) by athletes can cause detrimental effects on the liver, heart and arteries, kidneys, and hormonal systems. besides, it may cause mental health problems. objectives: the current study aimed to investigate the chronic effects of winstrol and oxandrolone anabolic steroids on liver enzymesin male bodybuilding athletes. methods: this causal-comparative study was conducted on 30 bodybuilding athletes living in yasuj city in 2019. participants wereincluded using the available and non-random sampling technique. then, were divided into three groups (each with 10 members), including: (1) athletes with no history of aas; (2) athletes with a history of aas (three months away from consumption); and (3) athletes with current aas consumption. after 12 hours of fasting, blood samples were taken in themorningtomeasure liver enzymes (ast, alt, and alp). data were analyzed by one-way analysis of variance (anova) and tukey post hoc test using spss version 21 at asignificance level of < 0.05. results: the resultsshowedhigher degradation of thetwoenzymesaspartate aminotransferase (ast)andalanine aminotransferase (ast) in the third group compared to the other two groups (p = 0.001, f = 130.84). also, the damage of ast and alt enzymes was more in the second group than the first group (p = 0.001, f = 188.178). also, the results of one-way analysis of variance showed no significant difference between groups concerning serum alp level (p = 0.227, f = 1.349). conclusions: steroid drugs have devastating effects on liver cells, even after three months of discarding their use, and the effectsnever get fully remedy, as they continue to affect consumers after quitting; however, it appears that the adverse effects on some liver enzymes significantly reduce over time.