تاثیر هشت هفته تمرینات مقاومتی خانگی بر سطوح ملاتونین، سروتونین، کیفیت خواب و کیفیت زندگی زنان مبتلا به بیماری اِم اِس

مولتیپل اسکلروزیس (ms) یک اختلال مزمن، پیش‌رونده و با واسطه ایمنی است که بر سیستم عصبی مرکزی تاثیر می‌گذارد و شایع‌ترین علت ناتوانی عصبی غیرتروماتیک در بزرگسالان است. هدف مطالعه حاضر، بررسی تاثیر هشت هفته تمرینات مقاومتی خانگی بر سطوح سرتونین، ملاتونین، کیفیت خواب و کیفیت زندگی در زنان مبتلا به بیماری ms بود. تعداد 27 بیمار زن (2.66 ± 34.56) مبتلا به ms از نوع عودکننده-فروکش‌کننده با امتیاز edss بین صفر تا 5.5 از مراجعه‌کنندگان به درمانگاه نورولوژی دانشگاه علوم پزشکی گیلان، به دو گروه تمرینات مقاومتی و گروه کنترل تقسیم شدند. برنامه تمرینات مقاومتی هشت هفته فعالیت ورزشی در منزل شامل چهار هفته فاز هایپرتروفی و چهار هفته فاز قدرت بود. کیفیت خواب و زندگی به ترتیب توسط پرسشنامه کیفیت خواب و پرسشنامه 26 سوالی کیفیت زندگی سازمان جهانی بهداشت ارزیابی شد. همچنین سطوح ملاتونین و سرتونین سرمی قبل و بعد دوره تمرین با استفاده از روش الایزا ارزیابی شد. داده مطالعه در سطح 0.05 با استفاده از روش آماری کوواریانس بررسی شد. بررسی ها نشان داد که سطوح ملاتونین، سرتونین و کیفیت زندگی و کیفیت خواب طی هشت هفته تمرینات مقاومتی تغییر معناداری نداشت (0.05

the effect of eight weeks of home-based resistance training on melatonin, serotonin levels, sleep quality, and quality of life in women with multiple sclerosis

background and purposemultiple sclerosis (ms) is an autoimmune and neurodegenerative disease of the central nervous system that causes neurological disability in adults. around 50% of ms patients experience sleep disorders such as insomnia and restless legs syndrome, which negatively affect their quality of life (qol). melatonin, a hormone involved in regulating the sleep/wake cycle, is found to be reduced in ms patients. studies suggest that melatonin supplementation can improve sleep quality and exert antioxidant effects. additionally, serotonin (5-ht), which is associated with depression and ms, is also reduced in patients. some antidepressant medications targeting the serotonergic system may help alleviate ms symptoms.physical activity, such as aerobic and resistance exercises, can help reduce ms symptoms and improve qol. however, due to limitations such as fatigue and depression, home-based exercise training (hbet) has been proposed as a practical solution. studies have shown that hbet has positive effects on physical health and qol in chronic conditions such as parkinson's disease and type 2 diabetes. however, its effectiveness in ms patients requires further investigation. the present study aims to evaluate the impact of hbet on melatonin and serotonin levels, sleep quality, and qol in women with ms. materials and methodsthis study was a practical and semi-experimental comparative investigation involving 700 patients with multiple sclerosis (ms) from gilan university of medical sciences' neurology clinic. the sample, determined using g*power software, included 27 female volunteers aged 25–50, with an expanded disability status scale (edss) score between 5–5.5, who met criteria such as no smoking, alcohol use, or comorbid conditions, and a relapsing-remitting ms diagnosis. participants were randomized into resistance and control groups. exclusion criteria included inconsistent training attendance or worsening symptoms. seven participants were excluded due to personal reasons or study protocol non-compliance.the resistance group underwent online training on proper exercise techniques, borg scale monitoring, and heart rate measurement. they received weighted vests and instructional videos for home-based resistance training (hbrt). the program included 3 weeks of educational sessions followed by an 8-week periodized hbrt protocol divided into hypertrophy (4 weeks) and strength (4 weeks) phases. training intensity was tailored individually using weights, fatigue levels, heart rate, and clinical conditions under physician supervision. each session included warm-ups, 25–30 minutes of resistance exercises, and cool-downs, with rest intervals of 2–4 minutes.the control group did not engage in any specific activity. blood samples were collected pre- and post-intervention after overnight fasting. physical assessments (e.g., height, weight, whr, body fat, blood pressure) were conducted at participants' homes. sleep quality and qol were measured using validated questionnaires. sleep metrics included subjective sleep quality, sleep duration, disturbances, medication use, and daytime dysfunction. qol evaluation encompassed physical function, emotional role, energy, social function, pain, and general health.data were analyzed using descriptive and inferential statistics (shapiro-wilk test, ancova, paired t-test) in spss 26, with significance set at p≤0.05. serum melatonin and serotonin levels were measured via elisa using elabscience kits. feedback was collected after each session for protocol adherence, and weights were adjusted biweekly during home visits to ensure progression. the results were intended to evaluate the effects of hbrt on sleep, qol, and biomarkers in ms patients. findings the results of the ancova test showed no significant differences in serotonin levels (f=0.05, p=0.827) and melatonin levels (f=0.132, p=0.722) between the two groups.