Effect of exercise on serum vitamin D and tissue vitamin D receptors in experimentally induced type 2 Diabetes Mellitus

This work aimed to study the effect of swimming exercise on serum vitamin d level and tissue vitamin d receptors in experimentally induced type 2 diabetes mellitus. sixty adult male rats were divided into control and diabetic groups. each was further subdivided into sedentary and exercised subgroups. diabetes mellitus was induced by a single intraperitoneal dose of streptozotocin (50 mg/kg) dissolved in cold 0.01 m citrate buffer (ph 4.5). the exercised subgroups underwent swimming for 60 min,5 times a week for 4 weeks. serum glucose,insulin,homeostasis model assessment of insulin resistance (homa-ir),lipids,vitamin d and tissue vitamin d receptors (vdr) were evaluated. significant increase in serum glucose,insulin,homa-ir,cholesterol,triglycerides,and low density lipoprotein (ldl) levels in sedentary diabetic rats was detected. on the other hand,high density lipoprotein (hdl),free fatty acids,serum vitamin d and pancreatic,adipose,and muscular vdr showed a significant decrease in the same group. it is evident that all these parameters were reversed by swimming exercise indicating its beneficial role in type 2 diabetes. in diabetic groups; serum vitamin d was found to be correlated negatively with serum glucose,insulin,homa,cholesterol,triglycerides,and ldl and positively correlated with hdl and tissue vdr. in conclusion,disturbed vitamin d is associated with metabolic impairments in sedentary diabetic rats. moderate swimming exercise is beneficial in improving these consequences through modulation of vitamin d status. future studies could be designed to investigate the effect of the combination of vitamin d intake with exercise in diabetic patients. © 2016