Evaluation of Salivary Immunoglobulin A Level in Thalassemic Patients With Periodontitis in Comparison With Thalassemic Patients With Healthy Periodontium

Background and aim: this study was conducted to evaluate salivary immunoglobulin a (iga) level in thalassemic patients with periodontitis in comparison to thalassemic patients with healthy periodontium. methods: seventy-five patients were included in this study and were divided into three groups, group a: 25 major thalassemic patients with mild to moderate periodontitis, group b: 25 thalassemic patients with healthy periodontium, and group c: 25 systemically healthy people with normal periodontium. to measure salivary iga levels, stimulated saliva was collected and analyzed by enzyme-linked immunosorbent assay (elisa). the data were analyzed by t-test, anova, and chi-square. results: salivary iga was significantly different in major thalassemia patients with periodontitis (69 μm/ml) in comparison to major thalassemia patients with healthy periodontium (81 μm/ml) (p < 0.05). the highest level of salivary iga was observed in the systemically healthy people with normal periodontium (88 μm/ml). conclusion: the levels of salivary iga were decreased in major thalassemia patients with periodontitis and healthy periodontium in comparison to systemically healthy people with normal periodontium.