magnetic nanoparticle hyperthermia for peritoneal metastasis-impact of tumor location and abdominal fat

Objective: this study investigates the impact of magnetic hyperthermia on the treatment of peritoneal metastases and analyzes the effects of abdominal fat and tumor position. the primary objective is to assess the effectiveness of localized heating with magnetic fields in eliminating cancer cells while minimizing damage to healthy tissue. method: in this study, magnetic nanoparticles fe₃o₄ were used to increase the temperature of tumor tissues to the range of 42-46 °c under the influence of an alternating magnetic field. a numerical simulation using the finite element method was conducted to analyze the impact of abdominal fat and tumor position on heat transfer, and the distribution of magnetic field intensity was calculated using maxwell's equations and the heat generated by nanoparticles based on rosensweig's theory. in this study, the heat generated by nanoparticles in the tumor has been incorporated into the pennes bioheat transfer equation, and the temperature distribution in the tumor and surrounding healthy tissues has been calculated. results: magnetic hyperthermia effectively eliminates cancer cells and performs well in areas with thick abdominal fat, which are challenging, so abdominal fat does not hinder hyperthermia. the tumor's position significantly affects heat distribution, and more precise adjustments are needed in areas with higher metastasis. this method can be used alone or with other treatments.