Synthesis and characterization of hydrazide-hydrazone derivatives of 3-pyridine carboxylic acid as antimycobac-terial tuberculosis agents

In this study synthesis of nicotinoyl hydrazone derivatives is investigated by introducing the nico-tinic acid hydrazide pharmacophore into several molecules and screening for antimycobacterial activity. benzaldehyde derivatives react with nicotinic acid hydrazide to form nicotinoyl hydra-zones. the synthesized compounds were screened against m. tuberculosis h37rv, clinical isolates of m. tuberculosis and mdr clinical isolates of m. tuberculosis using the proportion test. the mini-mum inhibitory concentration (mic) of n'-(4-methylphenyl) nicotinic acid hydrazone and n'-(4-(n,n-dimethyl)phenyl) nicotinic acid hydrazone exhibited activity between 40 and 200 ?g/ml and could be a good start point to find new lead compounds against m. tuberculosis.