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   Hepatoprotective Effects of Hertia cheirifolia Butanolic Extract and Selenium against CCl4-induced Toxicity in Rats  
   
نویسنده menakh mouna ,boutellaa saber ,mahdi djahida ,zellagui amar ,lahouel mesbah ,öztürk mehmet
منبع journal of reports in pharmaceutical sciences - 2021 - دوره : 10 - شماره : 2 - صفحه:216 -224
چکیده    Background: hertia cheirifolia, a traditional plant endemic to both tunisia and algeria, is used for the treatment of various disorders. this study investigates the antioxidant and protective effects of h. cheirifolia butanolic extract (behc) alone and combined with selenium (se) against carbon tetrachloride (ccl4)- induced liver damage in rats. experimental procedure: thirty male wistar rats were randomly divided into six groups: (1) normal control, (2) hepatotoxic control, (3) positive control received silymarin 100 mg/ kg body weight (bw), (4) behc (100 mg/kg bw), (5) behc (400 mg/kg bw), and (6) behc (400 mg/kg bw) + se (0,3 mg/kg bw) once daily for 14 consecutive days, followed by hepatotoxicity induction with ccl4 in olive oil 0.6 ml/kg bw intraperitoneally. some biochemical and oxidative stress parameters were investigated. quantity and quality of phenolics in behc were determined by spectrophotometer and high-performance liquid chromatography with diode-array detection (hplc-dad) analysis, respectively. results and conclusion: behc contained high amounts of total phenolics and flavonoids where seven compounds were identified. the pretreatment with behc or with behc and se significantly reduced the levels of plasma aminotransferases (alanine aminotransferase [ast] and aspartate aminotransferase [alt]), alkaline phosphatase, malondialdehyde (mda), and increasing glutathione (gsh), catalase (cat), and superoxide dismutase (sod) levels in hepatic tissues. in conclusion, behc has a potent natural antioxidant activity that can be used with se to reduce hepatotoxicity.
کلیدواژه Carbon tetrachloride ,hepatotoxicity in rat ,Hertia cheirifolia ,oxidative stress ,selenium
آدرس oum el bouaghi university, faculty of exact sciences and nature and life sciences, department of nature and life sciences, Algeria, oum el bouaghi university, faculty of exact sciences, laboratory of biomolecules and plant breeding, department of nature and life sciences, Algeria. university center abdehafid boussouf, department of nature and life sciences, Algeria, oum el bouaghi university, faculty of exact sciences and nature and life sciences, 1department of nature and life sciences, Algeria. badji mokhtar university, faculty of sciences, laboratory of animal eco-physiology, department of biology, Algeria, oum el bouaghi university, faculty of exact sciences, laboratory of biomolecules and plant breeding, department of nature and life sciences, Algeria, jijel university, faculty of sciences, laboratory of molecular toxicology, Algeria, muğla sıtkı koçman university, faculty of sciences, department of chemistry, Turkey
 
     
   
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