The Anti-Atherosclerotic Effect of Prosopis Farcta is Associated with the Inhibition of VCAM-1 and ICAM-1

This study evaluated the anti-atherosclerosis effect of aqueous extract and polysaccharide-enriched fraction of prosopis farcta on adhesion and inflammatory cascades in vascular endothelial cells and related molecular mechanisms. cellular toxicities of lps, plant extract and polysaccharide-enriched fraction were analyzed in vitro using the mtt method. the ros accumulation, mrna expression of icam1 and vcam1, and cox activity were measured in huvec cells. these results revealed a new underlying mechanism for anti-atherosclerosis effect of p. farcta and polysaccharide-enriched fraction by attenuating inflammatory cascade mediated by cox expression, modulating expression of celladhesion molecules including vcam-1 and icam-1, and diminishing oxidative stress agents.