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Synthesis of Novel Amide Containing Schiffs Bases of 5-(4- Chloro-Phenyl)-Furan-2-Carboxaldehyde: Their in Vivo Anti- Inflammatory, Antioxidant and Antinociceptive Activities with Ulcerogenic Risk Evaluation
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نویسنده
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haider saqlain ,alam mohammad sarwar ,hamid hinna ,umar sadiq ,kumar deepak ,nazreen syed
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منبع
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journal of reports in pharmaceutical sciences - 2018 - دوره : 7 - شماره : 1 - صفحه:44 -63
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چکیده
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A library of eighteen amide containing schiffs bases has been synthesized and screened for their anti-inflammatory, antioxidant and antinociceptive activities. the compound 2 (cox-1 ic50 = 63.23 μm; cox-2 ic50 = 1.80 μm; si = 35.12) exhibited potent selective cox-2 inhibition as compared to indomethacin (cox-1 ic50 = 3.60 μm; cox-2 ic50 = 7.50 μm; si = 0.48). the compounds 2 and 7 reduced the cox-2 level to 7.5 ±0.35 nmole/min/ml and 6.8 ± 0.32nmole/min/ml respectively. the compounds 6 exhibited reduced the tnf-α level to 3.36 ± 0.18pg/ml. the compounds 2, 6, 7, 13 and 17 did not induce any gastric ulceration in comparison to the standard drug indomethacin.
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کلیدواژه
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Prostaglandins ,Cox-2 Selectivity ,Tnf-α ,Glutathione ,Arthritis
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آدرس
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hamdard university, faculty of science, department of chemistry, India, hamdard university, faculty of science, department of chemistry, India, hamdard university, faculty of science, department of chemistry, India, hamdard university, faculty of science, department of toxicology, India, sikkim central university, department of pharmaceutical chemistry, India, hamdard university, faculty of science, department of chemistry, India
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Authors
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