Novel Super Saturated Self- Emulsifying System for Oral Delivery of Griseofulvin: Design, Preparation and ex-vivo Intestinal Permeability

The objective of the study was to prepare and design a stable formulation for self-emulsifying drug delivery system in order to enhance the solubility and oral absorption of a poorly-soluble drug, called griseofulvin. the prepared self-emulsifying systems were evaluated regarding their refractory index, particle size, emulsifying strength, drug release, and rat intestine permeability. the results showed that a mixture of oleic acid (as a fatty acid) with labrafil-tween 20 (as a surfactant), labrafac pg (as a cosurfactant), and poloxamer and hydroxypropyl methylcellulose (as a polymer) led to prepare stable emulsions with a refractive index higher than acidic medium and water. the particle size of the formulations was obtained between 310 to 834 nm. the particle size of samples was influenced by s/c ratios, so that the mean particle size decreases with an increasing in the s/c ratios. the percentage of drug release after 24 hours for formulations was 22.38 to 46.95. the correlation between the percentages of drug released after 24 hours with s/oil and s/c ratios was significant. in ex-vivo intestinal permeability, there was a significant and direct correlation between q4 and surfactant/oil ratio. the selected formulations showed drug permeability through the rat intestine 3- folds more, compared with the control.