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Hepatoprotective Effects of Combination Hydroalcoholic Extracts of Nigella Sativa and Curcuma Longa on Adriamycin- Induced Oxidative Stress in Rat
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نویسنده
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mohebbati reza ,khazdair mohammad reza ,karimi sareh ,abbasnezhad abbasali
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منبع
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journal of reports in pharmaceutical sciences - 2017 - دوره : 6 - شماره : 2 - صفحه:105 -114
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چکیده
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The ample of studies show that adriamycin caused hepatotoxicity in rat. the present study investigated the effects of nigella sativa (n. sativa) and combination with curcuma longa (c. longa) extract on adriamycin-induced hepatotoxicity in rat. rats were divided into eight experimental groups: control (co), adriamycin (adr), vitamin c (vit c), adriamycin with vitamin c (adr+vitc), n. sativa with and without adriamycin (ns +adr, ns -adr), combination extract of c. longa and n. sativa with and without adriamycin (ns+cl+adr, ns+cl-adr). malondialdehyde (mda) and thiol levels and also the activities of catalase (cat) in liver tissue were evaluated. mda level in the liver tissue in adr was increased compared to co group but in ns+adr group, adr+vitc and ns –adr groups decreased compared to adr group. thiol levels in adr and adr+vitc groups were decreased compared to co group. thiol levels in treatment groups were increased compared to adr group. the activities of cat in liver tissue of adr group were lower than co group, and increased in treatment groups comparison with adr group. the results showed that chronic administration of n. sativa hydroalcoholic extract in adriamycin-induced hepatotoxicity rats could decrease the oxidative stress injuries in liver tissue.
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کلیدواژه
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Adriamycin ,Curcuma Longa ,Nigella Sativa ,Hepatotoxicity ,Oxidative Stress
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آدرس
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medical university of mashhad, school of medicine, department of physiology, Iran, mashhad university of medical sciences, pharmaceutical research center, school of medicine, student research committee, department of physiology, iran, medical university of mashhad, school of medicine, department of physiology, Iran, gonabad university of medical sciences, faculty of medicine, department of basic sciences, Iran
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Authors
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