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synthesis,characterization, biological evaluation and anti corrosion activity of some new bis-piperidone derivatives
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نویسنده
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fahed hamak kholoud
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منبع
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international journal of advanced biological and biomedical research - 2013 - دوره : 1 - شماره : 2 - صفحه:186 -196
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چکیده
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Aseries of piperidine derivatives was synthesis by the reaction between substituted benzaldhyde ,pentanone-3,and ammonium acetate by refluxining for 1-2 hr in ethanol and the derivatives refluxed with (4,4'-diaminodiphenyl sulphone) yielded bispiperidine ,the structures of the synthesized compounds were confirmed by spectroscopy analysis ,the reported compounds were screened for their antibacterial activities against : staphylococcus aureus, lebsiella,escherichia coli,pseudomonas aeruginosa,salmonilla typhi, enterobacter. the synthesized piperidone-4 were tested to determine their ability to inhibit corrosion of mild steel in 1mol.l^-1 h2so4 and measured by polarization measurements .which showed that these compounds act as mixed-type inhibitors. the studies revealed that the nitrogen of schiff base and sulfur atome ,piperidine moiety ,and the phenyl ring assist largely in corrosion control.
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کلیدواژه
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piperidones-4 ,4'-diaminodipheylsulphone ,antibacterialactivity ,anticorrosion ,polarization ,bispiperidine
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آدرس
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damascus university, collegeof science, department of chemistry, syria
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پست الکترونیکی
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khlood.hamak@yahoo.com
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Authors
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