|
|
|
|
Dosage By High Performance Liquid Chromatography (Hplc) Coupled With the Dissolution of A Combination of Anti-Tuberculous: A Pilot Study Conducted in Cotonou, Benin
|
|
|
|
|
|
|
|
نویسنده
|
Baba-Moussa F. ,Bonou J. ,Ahouandjinou H. ,Dougnon V. ,Houndjo G. ,Gninafon M. ,Gangbo F. ,Toukourou F. ,Loko F. ,Aboudoulaye I. ,Kinde-Gazard D.
|
|
منبع
|
International Journal Of Advanced Biological And Biomedical Research - 2015 - دوره : 3 - شماره : 4 - صفحه:332 -340
|
|
|
|
|
چکیده
|
Efficient tuberculosis treatment requires the use of good quality medicines. the present study developed a method of dosage by high performance liquid chromatography (hplc) coupled with the dissolution of a combination of fixed doses of four antituberculous (isoniazid, pyrazinamide, ethambutol hydrochlorate, rifampicine). the elaborated protocol was thereafter used to assess the quality of medicines commonly used in benin as per the national program for tuberculosis control (pnt). an analytical procedure was developed and validated by statistical tests of cochran and grubbs. five lots of antituberculous were randomly sampled (from india and tuberculosis screening and treatment centres in benin). these lots were subjected to a number of tests including preliminary, disintegration, identifications and dissolution tests coupled with hplc and dosages. the established procedure is demonstrated to be applicable with 80% accuracy. results of the quality control revealed 100% conformity to all the tests for all tested drugs from all lots. the elaborated procedure is therefore applicable, rapid, effective and simple.
|
|
کلیدواژه
|
Anti-Tuberculous ,Quality Control ,Analytical Procedure
|
|
آدرس
|
Laboratoire National De Contrôle De Qualité Des Médicaments Et Consommables Médicaux (Lncq), Benin. Université D’Abomey-Calavi, Faculté Des Sciences Et Techniques, Isba-Champ De Foire Cotonou, Laboratoire De Microbiologie Et De Technologie Alimentaire, Benin, Laboratoire National De Contrôle De Qualité Des Médicaments Et Consommables Médicaux (Lncq), Benin. Université D’Abomey-Calavi, Faculté Des Sciences Et Techniques, Isba-Champ De Foire Cotonou, Laboratoire De Microbiologie Et De Technologie Alimentaire, Benin, Laboratoire National De Contrôle De Qualité Des Médicaments Et Consommables Médicaux (Lncq), Benin. Université D’Abomey-Calavi, Faculté Des Sciences Et Techniques, Isba-Champ De Foire Cotonou, Laboratoire De Microbiologie Et De Technologie Alimentaire, Benin, Université D’Abomey-Calavi, Ecole Polytechnique D’Abomey-Calavi, Laboratoire De Recherche En Biologie Appliquée, Benin, Laboratoire National De Contrôle De Qualité Des Médicaments Et Consommables Médicaux (Lncq), Benin, Ministère De La Santé, Programme National Contre La Tuberculose, Benin, Isba-Champ De Foire Cotonou, Laboratoire De Phytogénétique Et De Biologie Humaine, Benin, Université D’Abomey-Calavi, Faculté Des Sciences Et Techniques, Isba-Champ De Foire Cotonou, Laboratoire De Microbiologie Et De Technologie Alimentaire, Benin, Université D’Abomey-Calavi, Ecole Polytechnique D’Abomey-Calavi, Laboratoire De Recherche En Biologie Appliquée, Benin, Centre National Hospitalier Universitaire Hubert Koutoukou Maga (Cnhu - Hkm), Faculté Des Sciences De La Santé, Laboratoire De Biochimie, Benin, Université D’Abomey-Calavi, Faculté Des Sciences De La Santé, Laboratoire De Parasitologie Et De Mycologie, Benin
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|