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Selective Dispersive Solid Phase Extraction of Sertraline Using Surface Molecularly Imprinted Polymer Grafted on Sio2/Graphene Oxide
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نویسنده
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Khalilian Faezeh ,Khajoie Kermani Feloria
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منبع
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Journal Of Chemical Health Risks - 2017 - دوره : 7 - شماره : 1 - صفحه:49 -60
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چکیده
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A surface molecularly imprinted dispersive solid phase extraction coupled with liquid chromatography–ultraviolet detection is proposed as a selective and fast clean-up technique for the determination of sertraline in biological sample. surface sertraline-molecular imprinted polymer was grafted and synthesized on the sio2/graphene oxide surface. firstly sio2 was coated on synthesized graphene oxide sheet using sol-gel technique. prior to polymerization, the vinyl group was incorporated on to the surface of sio2/graphene oxide to direct selective polymerization on the surface. methacrylic acid, ethylene glycol dimethacrylate and ethanol were used as mono-mer, cross-linker and progen, respectively. non-imprinted polymer was also prepared for compar-ing purposes. the properties of the molecular imprinted polymer were characterized using field emission-scanning electron microscopy and fourier transform infrared spectroscopy methods. the surface molecular imprinted polymer was utilized as an adsorbent of dispersive solid phase extrac-tion for separation and preconcentration of sertraline. the effects of the different parameters influ-encing the extraction efficiency, such as sample ph were investigated and optimized. the specific-ity of the molecular imprinted polymer over the non-imprinted polymer was examined in absence and presence of competitive drugs. sertraline calibration curve showed linearity in the ranges 1–500 μg l^-1. the limits of detection and quantification under optimized conditions were obtained 0.2 and 0.5 μg l^-1. the within-day and between-day relative standard deviations (n=3) were 4.3 and 7.1%, respectively. furthermore, the relative recoveries for spiked biological samples were above 92%.
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کلیدواژه
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Biological Liquids Analysis; Sertraline; Dispersive Solid Phase Extraction; Sio2/Graphene Oxide; Surface Molecular Im-Printed Polymer
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آدرس
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Islamic Azad University, Yadegar -E-Imam Khomeini (Rah) Shahre Rey Branch, College Of Basic Science, Department Of Chemistry, ایران, Islamic Azad University, Yadegar -E-Imam Khomeini (Rah) Shahre Rey Branch, College Of Basic Science, Department Of Chemistry, ایران
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پست الکترونیکی
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faezeh.khalilian@yahoo.com
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Authors
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