selective dispersive solid phase extraction of sertraline using surface molecularly imprinted polymer grafted on sio2/graphene oxide

A surface molecularly imprinted dispersive solid phase extraction coupled with liquid chromatography–ultraviolet detection is proposed as a selective and fast clean-up technique for the determination of sertraline in biological sample. surface sertraline-molecular imprinted polymer was grafted and synthesized on the sio2/graphene oxide surface. firstly sio2 was coated on synthesized graphene oxide sheet using sol-gel technique. prior to polymerization, the vinyl group was incorporated on to the surface of sio2/graphene oxide to direct selective polymerization on the surface. methacrylic acid, ethylene glycol dimethacrylate and ethanol were used as mono-mer, cross-linker and progen, respectively. non-imprinted polymer was also prepared for compar-ing purposes. the properties of the molecular imprinted polymer were characterized using field emission-scanning electron microscopy and fourier transform infrared spectroscopy methods. the surface molecular imprinted polymer was utilized as an adsorbent of dispersive solid phase extrac-tion for separation and preconcentration of sertraline. the effects of the different parameters influ-encing the extraction efficiency, such as sample ph were investigated and optimized. the specific-ity of the molecular imprinted polymer over the non-imprinted polymer was examined in absence and presence of competitive drugs. sertraline calibration curve showed linearity in the ranges 1–500 μg l^-1. the limits of detection and quantification under optimized conditions were obtained 0.2 and 0.5 μg l^-1. the within-day and between-day relative standard deviations (n=3) were 4.3 and 7.1%, respectively. furthermore, the relative recoveries for spiked biological samples were above 92%.