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Biological Activity and Efficient Synthesis of 3, 4-Dihydropyrimidin-2-(1h)-One/Thione Derivatives
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نویسنده
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Hatamjafari Farhad
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منبع
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Journal Of Chemical Health Risks - 2014 - دوره : 4 - شماره : 4 - صفحه:55 -61
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چکیده
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The present study aimed to use a method for the synthesis of some 3, 4- dihydropyrimidin-2-(1h) - ones/thiones. the study tried to answer the question whether this reaction can be performed without solvent and with new catalyst or not. to find answer to the question, we described a novel protocol for the efficient synthesis of 3, 4-dihydropyrimidin-2- (1h)-one derivatives using aromatic aldehyde, ethylacetoacetate, and urea/thiourea under solventfree conditions by using sio2-cacl2 as a catalyst. using this catalyst has some advantages; it's high yields, usable in mild conditions, available, reusable, ecofriendly, cost effective and environmentally friendly. the structural features of the synthesized compounds were characterized by ir, ^1h nmr and ^13c nmr. the compounds were screened for antimicrobial activity. the results showed these compounds react against all the tested bacteria. we have demonstrated a novel method for the synthesis of substituted dihydropyrimidinones catalyzed by sio2-cacl2 under solvent-free conditions.
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کلیدواژه
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Antimicrobial Activities Silica Supported Calcium ,4-Dihydropyrimidin-2-(1h)-One/Thione ,One-Pot ,Solvent-Free Conditions
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آدرس
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Islamic Azad University, Tonekabon Branch, Faculty Of Science, Department Of Chemistry, ایران
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پست الکترونیکی
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f_hatamjafari@tonekaboniau.ac.ir
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Authors
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