synthesis, characterization, and computational, biological studies of four-membered cyclic amides 2- azetinones

Two compounds,3-benzoyl-2-(4-bromophenyl)-3-phenyl-6 – oxa-2-azaspiro[3.4]octan-1-one and 1',1'''-bis(3-bromo-4-(dimethylamino)phenyl)-4,4'''',5,5''''-tetrahydro-2h,2''''h-tetraspiro[furan-3,2'-azetidine-4',1''-acenaphthylene-2'',2'''-azetidine-3''',3''''-furan]-3',4'''-dione, were synthesized by tetrahydro furan-3-carboxylic acid and appropriate imines. two studies were conducted on the prepared compounds, one of them is the study of their anti-biological efficacy using two types of bacteria staphylococcus aureus and escherichia coli, the other study that was conducted on the compounds is a computational study to calculate some of the thermodynamic parameters of synthesized derivatives by using a gaussian program.