Synthesis and Antimicrobial Activity of 5-Chloro-1-Ethyl-2-Methylimidazole-4-Sulfonyl-8-Quinolinoxide

A new 5-chloro-1-ethyl-2-methylimidazole-4-sulfonyl-8-quinolinoxide was synthesized starting from diethyloxalate via a four-reaction step. the new compound obtained in a simple and efficient procedure in the solvent and solvent-free with good yield and methanol served as a precipitating agent to isolate compound 2. the purity of 5- chloro-1-ethyl-2-methylimidazole-4-sulfonyl-8-quinolinoxide was tested by thin-layer chromatography (tlc) and characterized by fourier transform infrared spectroscopy (ft-ir), proton nuclear magnetic resonance (nmr), carbon-13 (c13) nuclear magnetic resonance (13c-nmr), and dept 135 to confirm the presence and nature of ch2. the solvent-free reaction of compound 1 was better in relation to green chemistry and better yield. the presence of solvent responsible for a color change that differentiates between compound 1 and 2 as they have the same physical data, functional group, and the chemical shift studied. the newly synthesized compound was evaluated and screened in vitro against gram-positive (methicillin-susceptible staphylococcus aureus, methicillin-resistant staphylococcus aureus, and bacillus subtilis), gram-negative (pseudomonas aeruginosa, escherichia coli, and klebsiella pneumoniae) bacterial strains, and candida albicans using the standard microbiological method. 5-chloro-1-ethyl-2- methylimidazole-4-sulfonyl-8-quinolinoxide exhibited weak activities when compared with the standard drug ciprofloxacin and itraconazole used for many bacterial and fungal infections respectively.