|
|
|
|
Synthesis and application of some Drug-conjugated Poly p-styrene sulphonate for drug release Delivery
|
|
|
|
|
|
|
|
نویسنده
|
خزایی اردشیر ,امینی منش عباس ,گلباغی مریم
|
|
منبع
|
شيمي كاربردي روز - 2012 - دوره : 7 - شماره : 23 - صفحه:11 -19
|
|
چکیده
|
Controlled drug release is one of the most important methods to increase the therapeutic effects and decrease side effects of drug. in this research, three drugs (piperazine, 8-aminoquinoline, n-phenyl piperazine) were attached chemically to the p-styrene sulphonyl chloride (as monomer), and they were polymerized by aibn ( azobis isobutyro nitrile) at 80 °c. finally, release ability of three polymer-drugs were tested in buffer solution with ph= 1.3 at the temperature 37 °c. the gpc spectra of the polymers showed that polymerization of monomers containing drugs were carried out. the results established that, these polymeric systems are able to release drugs.
|
|
کلیدواژه
|
drug ,p-styrene sulphonylchloride monomer ,polymerization ,drug delivery
|
|
آدرس
|
bu ali sina university of hamadan, Professor of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran, ایران, payame noor university, Department of Chemistry, Payame Noor University, Tehran, I R of IRAN, ایران, payame noor university, Department of Chemistry, Payame Noor University, Tehran, I R of IRAN, ایران
|
|
پست الکترونیکی
|
-
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|