|
|
|
|
investigation of the cytotoxic potencies of substituted dipyrrolo[1,2-a:2',1'-c]pyrazines and substituted pyrrolo[2'',1'':3',4']pyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-8(9h)-ones
|
|
|
|
|
|
|
|
نویسنده
|
barghi lish azam ,kolvari eskandar ,foroumadi alireza ,koukabi nadiya
|
|
منبع
|
شيمي كاربردي روز - 2024 - دوره : 19 - شماره : 73 - صفحه:55 -72
|
|
چکیده
|
Cancer is the world's second leading cause of death after cardiovascular diseases. the data reported by the world health organization (who) about this disease indicates a troubling increase in both prevalence and mortality over the past decade. consequently, significant efforts have been directed toward the discovery and development of a new and potent anticancer agents. in an attempt to find and develop further new compounds possessing cytotoxic potencies, the efficient, simple, and multi-step synthetic routes were employed to afford various substituted dihydrodipyrrolo[1,2-a:2',1'-c]pyrazine-2,3-dicarboxylates 8a-8s, which were subsequently subjected to cyclization in the presence of hydrazine hydrate to produce tetrahydropyrrolo[2'',1'':3',4']pyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-8(9h)-ones 10a-10q. afterwards, their cytotoxicity were examined against five human cancerous cell lines, including mcf7, hela, sw480, hepg2, and a549 by using the mtt colorimetric assay. considering the results, further evaluations were conducted on the compound 8l, which exhibited the induction of apoptosis and g0 cell cycle arrest in mcf7 and a549 cells.
|
|
کلیدواژه
|
cytotoxic ,pyrrole pyrazine ,cell-cycle.
|
|
آدرس
|
semnan university, department of chemistry, iran, semnan university, department of chemistry, iran, tehran university of medical sciences, faculty of pharmacy, department of medicinal chemistry, iran. the institute of pharmaceutical sciences (tips), drug design and development research center, iran, semnan university, department of chemistry, iran
|
|
پست الکترونیکی
|
n.koukabi@gmail.com
|
|
|
|
|
|
|
|
|
|
|
|
|
|
investigation of the cytotoxic potencies of substituted dipyrrolo[1,2-a:2',1'-c]pyrazines and substituted pyrrolo[2'',1'':3',4']pyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-8(9h)-ones
|
|
|
|
|
Authors
|
barghi lish azam ,kolvari eskandar ,foroumadi alireza ,koukabi nadiya
|
|
Abstract
|
cancer is the world's second leading cause of death after cardiovascular diseases. the data reported by the world health organization (who) about this disease indicates a troubling increase in both prevalence and mortality over the past decade. consequently, significant efforts have been directed toward the discovery and development of a new and potent anticancer agents. in an attempt to find and develop further new compounds possessing cytotoxic potencies, the efficient, simple, and multi-step synthetic routes were employed to afford various substituted dihydrodipyrrolo[1,2-a:2',1'-c]pyrazine-2,3-dicarboxylates 8a-8s, which were subsequently subjected to cyclization in the presence of hydrazine hydrate to produce tetrahydropyrrolo[2'',1'':3',4']pyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-8(9h)-ones 10a-10q. afterwards, their cytotoxicity were examined against five human cancerous cell lines, including mcf7, hela, sw480, hepg2, and a549 by using the mtt colorimetric assay. considering the results, further evaluations were conducted on the compound 8l, which exhibited the induction of apoptosis and g0 cell cycle arrest in mcf7 and a549 cells.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|