using the design experiment response surface methodology for the preparation of three-component nanoparticles

In this study, threecomponent nanoparticles of iron, nickel and lithium were synthesized with two methods of combined technique (coprecipitation, hydrothermal) and pechini solgel. the optimum conditions for producing magnetic nanoparticles (mnps) by coprecipitation method were found to be at ph=13 with constant stirring rate of 1000 rpm and at temperature of 72 ˚c under nitrogen atmosphere. the situation for preparing nanoparticles by pechini solgel method including dissolving nitrate salt of three metals in water then adding citric acid and ethylene glycol respectively in temperatures 60 and 80 0 c with ph=7 and placing sample in temperatures 190 and 500 0 c for 720 and 60 minutes respectively. in the comparison of two methods, morphology and size of produced magnetic nanoparticles with combined method of coprecipitation hydrothermal was more suitable. response surface methodology was used to verify the best synthesized nanoparticles in size. the surface of mnps was modified with silica and amine groups to develop a suitable drug delivery system.

Using the design experiment RSM for the preparation of nanoparticles containing pyrazinamide, ethambutol and rifampin

In this study, threecomponent nanoparticles of iron, nickel and lithium were synthesized with two methods of combined technique (coprecipitation, hydrothermal) and pechini solgel. The optimum conditions for producing magnetic nanoparticles (MNPs) by coprecipitation method were found to be at pH=13 with constant stirring rate of 1000 rpm and at temperature of 72 ˚C under nitrogen atmosphere. The situation for preparing nanoparticles by pechini solgel method including dissolving nitrate salt of three metals in water then adding citric acid and ethylene glycol respectively in temperatures 60 and 80 0 C with pH=7 and placing sample in temperatures 190 and 500 0 C for 720 and 60 minutes respectively. In the comparison of two methods, morphology and size of produced magnetic nanoparticles with combined method of coprecipitation hydrothermal was more suitable. Response surface methodology was used to verify the best synthesized nanoparticles in size. The surface of MNPs was modified with silica and amine groups to develop a suitable drug delivery system.