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mwcnts modified carbon paste electrode for sensitive determination of antiparkinson drug entacapone in the bulk, pharmaceutical and human biological human samples
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نویسنده
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boutorabi leila ,asghari alireza ,rajabi maryam
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منبع
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شيمي كاربردي روز - 2019 - دوره : 13 - شماره : 49 - صفحه:79 -88
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چکیده
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In this paper, the voltammetric properties of entacapone, an antiparkinson’s disease drug, were investigated by cyclic voltammetry and differential pulse voltammetry at mwcnts modified carbon paste electrode in phosphate buffer in presence of tween 20 and validated for quantitative determination of entacapone in bulk, pharmaceutical dosage forms and human plasma. several factors such as ph, type of surfactant and scan rate were investigated in order to study the optimum conditions for determination of entacapone. a good linear relationship was obtained within the concentration range from 50 ˟ 109 to 2.4˟103m. the limits of detection and limit of quantification were found to be 8×1010and 2.4×109moll1, respectively. the proposed method was simple, rapid and economic, so it is suitable for routine analysis of entacapone in pure form and dosage forms and for pharmaco kinetic studies.
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کلیدواژه
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entacapone ,tween20 ,carbon paste electrode ,multiwalled carbon nanotubes ,cyclic voltammetry ,differential pulse voltammetry
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آدرس
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semnan university, department of chemistry, lran, semnan university, department of chemistry, lran, semnan university, department of chemistry, lran
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MWCNTs modified carbon paste electrode for sensitive determination of antiparkinson drug entacapone in the bulk, pharmaceutical and human biological human samples
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Authors
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Boutorabi seyedeh Leila ,Asghari Alireza
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Abstract
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In this paper, the voltammetric properties of entacapone, an antiParkinson’s disease drug, were investigated by cyclic voltammetry and differential pulse voltammetry at MWCNTs modified carbon paste electrode in phosphate buffer in presence of Tween 20 and validated for quantitative determination of entacapone in bulk, pharmaceutical dosage forms and human plasma. Several factors such as pH, type of surfactant and scan rate were investigated in order to study the optimum conditions for determination of entacapone. A good linear relationship was obtained within the concentration range from 50 ˟ 109 to 2.4˟103M. The limits of detection and limit of quantification were found to be 8×1010and 2.4×109molL1, respectively. The proposed method was simple, rapid and economic, so it is suitable for routine analysis of entacapone in pure form and dosage forms and for pharmaco kinetic studies.
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Keywords
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entacapone ,Tween20 ,Carbon paste electrode ,Multiwalled carbon nanotubes ,Cyclic voltammetry ,Differential pulse voltammetry
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