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synthesis, characterization and comparative study of cytotoxic effect of copper(ii) and zinc β-diketonate complexes
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نویسنده
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eshaghi malekshah rahimeh ,salehi mehdi ,khaleghian ali
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منبع
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شيمي كاربردي روز - 2017 - دوره : 11 - شماره : 41 - صفحه:165 -170
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چکیده
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Two mononuclear complexes [znii(maa)(phen)(cl)] (a) and [cuii(tta)2] (b) (tta = 4,4,4-trifluoro-1-(2-furyl)-1,3-butanedione), (maa = methyl acetoacetate and phen = 1,10-phenanthroline) were synthesized and fully characterized by uv–vis and ftir spectroscopy. in this study, the mkn-45 cell line used for mtt assay. two complexes exhibited lethal effects against mkn-45 cell lines compared to the untreated control. the ic50 is observed about 1 μg/ml for both complexes. besides, the migration studies revealed that complex (b) is more active than complex (a) against the mkn-45 cancer cell lines. in morphology assay, it was also found that many of the cells showed cytoplasmic shrinkage and loss of normal nuclear architecture.
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کلیدواژه
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β-diketone ,l0-phenanthroline ,cytotoxicity effect ,migration assay
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آدرس
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semnan university, department of chemistry, ایران, semnan university, department of chemistry, ایران, semnan university of medical sciences, faculty of medicine, biochemistry department, ایران
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Synthesis, characterization and comparative study of cytotoxic effect of copper(II) and zinc βdiketonate complexes
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Authors
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Abstract
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Abstract Two mononuclear complexes [ZnII(MAA)(phen)(Cl)] (A) and [CuII(TTA)2] (B) (TTA = 4,4,4Trifluoro1(2furyl)1,3butanedione), (MAA = methyl acetoacetate and phen = 1,10phenanthroline) were synthesized and fully characterized by UV–Vis and FTIR spectroscopy. In this study, the MKN45 cell line used for MTT assay. Two complexes exhibited lethal effects against MKN45 cell lines compared to the untreated control. The IC50 is observed about 1 µg/mL for both complexes. Besides, the migration studies revealed that complex (B) is more active than complex (A) against the MKN45 cancer cell lines. In morphology assay, it was also found that many of the cells showed cytoplasmic shrinkage and loss of normal nuclear architecture.
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Keywords
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l0phenanthroline ,Cytotoxicity effect ,Migration assay
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