Association of 1661A/G Cytotoxic T lymphocyte Antigen-4 (CTLA-4) Gene Polymorphism With a Clinical Subset of Iranian Children With Systemic Lupus Erythematosus

Background: cytotoxic t-lymphocyte antigen-4 (ctla-4) is a molecule engaged in regulation of t cells. polymorphisms in the ctla-4 gene (ctla4) are known to be associated with several autoimmune diseases, including systemic lupus erythematosus. objectives: to evaluate the potential influences of common snp in ctla-4 promoter region (-1661 a/g), a case-control study was performed on iranian children. patients and methods: genotypes of 31 patients and 50 healthy controls were investigated using the polymerase chain reactionrestriction fragment length polymorphism (pcr-rflp) method. results: our study showed that there were no statistically significant differences in the allele and genotype frequencies of -1661 a/g snp between patients with sle and healthy controls (p > 0.05). conclusions: in conclusion, we found no association between snp-1661 a/g of the ctla-4 promoter region and susceptibility to sle in our population.