Effect of Resistance Training on Adipose Tissue and Serum METRNL Levels in Sucrose Solution Fed Rats

Background: meteorin-like protein (metrnl) is a novel adipomyokine that may improve glucose tolerance, and its circulating levels are affected by changes in body weight. objectives: this study aimed to evaluate the effects of eight weeks of resistance training (rt) and high sucrose consumption on serum and adipose tissue metrnl levels in male rats. methods: in this study, 32 wistar male rats were divided into normal diet and high sucrose diet groups. after 4 weeks, each group was divided into control and training groups. the rats in the training group were subjected to the rt program (3 days/week, for 8 weeks). in addition to serum and adipose tissue levels of metrnl,wemeasured epididymal and mesenteric fat mass, serum glucose, insulin, and homeostatic model assessment of insulin resistance (homa-ir). results: high sucrose diet increased fat weights and serum levels of glucose, insulin, and ir index; nevertheless, it reduced the serum levels of metrnl. rt decreased serum insulin concentrations and homa-ir. the result of two-way anova and the t-test showed that eight weeks of rt decreased serum levels of metrnl, insulin, and homa-ir in sugar solution-fed rats. conclusions: the results suggest that rt may be an effective intervention to reduce serum metrnl and homa-ir levels, which is associated with improving body composition.