histological and behavioral alterations following hadscs intravenous administration in alzheimer's rat model

Background: alzheimer’s disease (ad) is a progressive cognitive disorder that is generally age-related. although there has beengreat research focusing on this disease, there is still a lack of reliable therapeutic methods. amyloid- (a) peptide has a criticalfunction in neuropathology of ad. stem cell therapy provides treatment by improving the neuronal system in neurodegenerativedisorders. human adipose-derived stem cells (hadscs) are the most appropriate sources of stem cells due to their safety, high proliferativepotential, and easy isolation.objectives: the present studywas designed to evaluate the histologicalandbehavioral alterations after intravenous administrationof hadscs in the ad rat model.methods: in this study, 32 male rats were used in four groups, as follows: control, sham, ad rat model, and hadscs-treated group.we used morriswater maze (mwm) for evaluating behavioral changes and nissl staining for determining the histological studies.results: in this study, the ad model was confirmed by behavioral and histological analysis. behavioral results showed that thespatial memory improved after hadscs injection in the ad rat model while the time spent in the target quadrant was significantlyhigher in the hadscs-treated group than in the ad rat model group. on the other hand, the number of dead cells significantlydecreased in the hadscs-treated group as analyzed by nissl staining.conclusions: our findings revealed that hadscs could transfer into the brain and improve memory and neuronal damage in thead rat model.