>
Fa   |   Ar   |   En
   Consistent absence of BRAF mutations in salivary gland carcinomas  
   
نویسنده mohtasham nooshin ,ayatollahi hossein ,ghazi narges ,jafarian amirhossein ,roshanmir azam ,mohajertehran farnaz
منبع journal of dental materials and techniques - 2017 - دوره : 6 - شماره : 2 - صفحه:73 -78
چکیده    Introduction: malignant salivary gland tumors are rare entities. despite advances in surgery, radiation therapy and chemotherapy, the rate of the mortality and five-year survival has not been improved markedly over the last few decades. the activation of egfr- ras-raf signaling pathway contributes to the initiation and progression of many human cancers, promising a key pathway for therapeutic molecules. thus, the objective of this study was to evaluate braf mutations in salivary gland carcinomas. methods: we designed pcr- rflp (polymerase chain reaction -restriction fragment length polymorphism) and screened 50 salivary gland carcinomas (sgcs) including mucoepidermoid carcinoma (mec), adenoid cystic carcinoma (adcc) and polymorphous low grade adenocarcinoma (plga) for the braf v600e mutation. results: pcr-rflp analyses demonstrated no mutation in braf exon 15 for sgc samples at position v600, which is the most commonly mutated site for braf in human cancer. conclusions: according to our results sgcs didn’t acquire braf mutations that result in a constitutive activation of the signaling cascade downstream of egfr, hence sgcs can be a good candidate for anti egfr therapies.
کلیدواژه BRAF ,EGFR ,Salivary gland carcinoma
آدرس mashhad university of medical sciences, oral & maxillofacial diseases research center, school of dentistry, department of oral and maxillofacial pathology, ایران, mashhad university of medical sciences, faculty of medicine, department of hematology and blood bank, ایران, mashhad university of medical sciences, school of dentistry, dental research center, department of oral & maxillofacial pathology, ایران, mashhad university of medical sciences, faculty of medicine, department of pathology, ایران, golestan university of medical sciences, school of dentistry, department of oral and maxillofacial pathology, ایران, mashhad university of medical sciences, dental research center, ایران
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved