Verapamil all-solid-state sensor and its application for the analysis of pharmaceutical formulations

An all-solid-state polymeric membrane electrode (ass-pme) has been constructed for the analysis of verapamil (vp) which is a calcium channel blocker used in the management of angina,arrhythmia and hypertension. the pme element of the ass-pme has been based on the application of an ion-pair sensing reagent and the results revealed the best sensing behavior to occur in the case of compositions of 6%wt vp-tetraphenyl borate (the sensing element),62%wt dioctyl phthalate as the solvent mediator,30%wt poly(vinyl chloride) and 2%wt of an ionic liquid. the ass element,on the other hand,is made of a composite of graphite,multiwall carbon nanotubes (mwcnts),and epoxy resin coated on a cu wire. the response behavior of the ass-pme device was found to be linear from 1.0×10-7 to 1.0×10-3 m,with a slope of 55.3±0.2 mv/decade and a detection limit of 7.0×10-8 m was reached under the optimal conditions. the device was also successfully used in the real sample analysis. © 2016,center of excellence in electrochemistry,univ. of tehran. all rights reserved.